Dutasteride waxaa loo suuq geeyaa farmashiyaha sida Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost.Sababo aan la garanayn, tijaabooyinkii hore ee kiliinikada ee dutasteride ayaa si lama filaan ah loo joojiyay 2002, ka dibna way sii socdeen mar dambe.

Dutasteride waa 5-alpha-reductase inhibitor, taas oo macnaheedu yahay in ay xannibayso ficilka 5a-reducase enzymes, kuwaas oo mas'uul ka ah 5a-yaraynta (beddelidda) testosterone galay dihydrotestosterone (DHT) iyada oo lagu daro isku-xidhka hydrogen double.

Dutasteride waxay joojisaa labadaba isoforms ee 5a-reductase, sidaas darteed ka hortagga beddelka testosterone ee dihydrotestosterone.Tani waxay Dutasteride ka dhigaysa daaweyn macquul ah oo loogu talagalay Bidaarta Qaabka Labka ah.Dabcan, marka aad u beddesho Testosterone ka yar galay Dihydrotestosterone, waxaad kordhisaa heerarka testosterone by default (beddelka yar).

Dutasteride, at 2.5mgs / maalin waa qiyaastii 1.5x ka waxtar badan Finasteride at 5mgs / maalin, marka lagu daaweeyo timo lumis (labadaba joojinta iyo sidoo kale dib u soo kabashada).Intaa waxaa dheer, Dutasteride waxaa loo isticmaali karaa si guul leh isla qiyaastaas si loo daaweeyo bararka qanjirka 'prostate', iyo saameynta yar ee la yaqaan ee Dutasteride (mar kale, isla qiyaastaas) isticmaalka waa in lagu daaweeyo finanka oo ay keento xad-dhaaf ah androgens ee jirka.

Isticmaalka steroid-ka ee isticmaalaya cayaartoyga la ildaran waxyeellooyinka la xidhiidha DHT, Dutasteride ayaa laga yaabaa inay noqoto jawaabta.Timo-jarida, finanka, iyo korriinka qanjidhka qanjirka 'prostate' ayaa dhamaantood (macquul ah) si buuxda loo joojin karaa isticmaalka alaabtan.Nasiib darro, DHT ma wada xun, waxaana suurtogal ah in aad lumiso xoogaa adkaanta muruqa (tayada amorphous haddii ay weligeed jirto), iyo xitaa qaar ka mid ah tayada kale ee aan ka jecelnahay isticmaalka androgen.

Sidoo kale…maadaama ay tani kaliya ka hortagayso 5a-yaraynta androgens ee ku xidhan u beddelashada qaab dihydro iyaga ka mid ah… waxay u badan tahay inayna waxba kama qaban doonto joojinta timo-la'aanta ama calaamado kale oo ay sababto gebi ahaan isticmaalka androgens ee qoyska DHT.

Dutasteride, oo ay weheliso Finasteride waa 5-alpha-Reductase inhibitor kuwaas oo ah koox dawooyin ah oo leh sifooyinka anti-androgenic kuwaas oo xakameynaya beddelka testosterone ee dihydrotestosterone (DHT).Tani waa isla kiimiko laga helay Proscar iyo Propecia waxaana loo isticmaalaa daawaynta hyperplasia iyo alopecia androgenic.Sababtoo ah dawooyinkani waxay yareeyaan heerarka dihydrotestosterone (DHT) waxaa loo isticmaalaa ka hortagga iyo daweynta timaha.Waxaa inta badan loo isticmaalaa in lagu daweeyo qanjidhada prostate ka oo weyn.