Farsamooyin cusub

1) bayotechnoolajiyada: farsamada injineernimada hidaha, tignoolajiyada biotransformation hufan, tignoolajiyada catalysis enzyme ee warshadaha

2) Chemistry Cagaaran: falcelinta qallafsanaanta, xalalka reagent cagaaran, habka xoojinta farsamada

Heerkulka falcelinta: - 100 ℃ ~ 150 ℃

Cadaadiska falcelinta hydrogenation-ka: cadaadiska atmospheric ~ 5 MPa

Noocyada falcelinta: falcelinta Grignard, falcelinta hydrogenation, falcelinta redox ee xulashada, falcelinta dib u habeynta, falcelinta dareen-celinta, falcelinta fluorination, falcelinta Foucault, falcelinta kicinta enzyme, iwm

Gaar ahaan, waxaan leenahay waayo-aragnimo qani ah, asal xirfadeed iyo injineernimo xooggan iyo awood-kordhinta ee isku-xir kasta oo ah baaritaanka dariiqa synthetic, horumarinta habka horumarinta, xoojinta habka iyo hirgelinta.

Natiijadu: Wanaaji hufnaanta, dhimi kharashaadka, oo beddel xaaladda cakiran ee wasakhowga sare iyo isticmaalka tamarta sare.

Habka Wax-soo-saarka ee Isku-dhafan Steroid

Hababka caadiga ah waa isku-darka kiimikada iyo isbeddelka microbial, kaas oo isbeddelka microbial uu door muhiim ah ka ciyaaro habka wax soo saarka oo dhan.Xaddidaadda ugu weyn ee habka isku-dhafka kiimikaad ee lagu dabaqo isku-dhafka stereochemical waxay ku jirtaa xulashada liidata.Qeexitaanka sare ee falcelinta ensaymatiga ee ay koolkoolinayaan enzymes noolaha ayaa ka dhigi kara yaraanta Kiimikada Synthesis.Soo bandhigida enzymes-ka ee steroids ayaa loo beddelay qaab ku habboon.

Catalysis microbial enzymatic catalysis waa u beddelashada qayb gaar ah (ama koox) oo ka mid ah xarunta organic galay xarun kale oo la mid ah qaab ahaan.Wax soo saarka kama dambaysta ah ee isbeddelka aan la soo saarin iyada oo loo marayo taxane ah hababka dheef-shiid kiimikaadka unugyada microbial, laakiin waxaa sameeyay fal-celin kiimikaad ee qayb gaar ah oo ka mid ah substrate-ka iyadoo la adeegsanayo nidaamka enzyme ee unugyada microbial.Dareen-celinta isbeddelka microbial ee steroids waa kala duwan yihiin, waxayna awood u leeyihiin inay bioconvert atomi ama kooxo goob kasta oo steroids ah, oo ay ku jiraan xudunta waalidka iyo silsiladaha dhinaca, waxaa jira oksaydhyo, hoos u dhac, hydrolysis, esterification, acylation, isomerization, halogenation, a furitaanka giraanta, hoos u dhaca silsiladda dhinac.Mararka qaarkood microbe sidoo kale isku mar isku mar la kulmi karaan dhowr falcelin oo kala duwan.Hydroxylation waa mid ka mid ah falcelinta ugu muhiimsan ee isbeddelka microbial ee steroids.Microorganisms-ku waxay samayn karaan fal-celin hydroxylation meel kasta oo steroids ah, laakiin habka kiimikaad waa adag tahay in lagu soo bandhigo hydroxyl meelo kale marka laga reebo C-17.Isku-dhafka kiimikada iyo isbeddelka microbial waa hab wax-soo-saarka wax ku ool ah, kaas oo si weyn u kor u qaada wax soo saarka warshadaha ee daawooyinka steroid.

Faa'iidooyinka Farsamada

1)Nidaamka halsano oo dhamaystiran

2) Si loo xaqiijiyo adeegsiga tignoolajiyada waraabowga kiimikada ee kala duwan

3) Soo saarista iyo horumarinta isticmaalka enzyme

4) Isku darka qumman ee beddelka kala duwan