T3 Liothyronine Sodium CAS 55-06-1 budada steroid anabolic afka ee luminta dufanka
Faahfaahin Degdeg ah
Magaca alaabta: Liothyronine Sodium (T3)
Magaca: Cytomel T3;3, 3', 5-triiodothyronine sodium;T3
Einecs No: 200-223-5
MF: C15H11I3NNaO4
CAS No: 55-06-1
MW: 672.96
Daahirsanaanta: 99.0%
Muuqaalka: caddaan ilaa budada beige
Isticmaalka: Hormoonnadani waxay sidoo kale nidaamiyaan borotiinka, baruurta, iyo dheef-shiid kiimikaadka karbohaydrayt, taas oo saameeya sida unugyada bini'aadamka u isticmaalaan xeryahooda tamarta leh.
Qiyaasta T3
T3 waxay dedejisaa luminta dufanka.Sida tilmaame, inta badan 12.5 mcg/maalintii waa nooc ka mid ah qiyaasta "kabka" muxaafidka ah oo u muuqda in aanay saameyn xun ku yeelanayn shaqada tayroodh gabi ahaanba.
25 mcg/maalintii waa nooc ka mid ah qaadashada "kabka" taas oo leh xoogaa saameyn celin ah.
50 mcg/maalintii waa qiyaas muxaafid macquul ah oo bb'ing ah, kaas oo, dabcan, aad u xaddidan.aragti.
75 mcg/maalintii waxay gelaysaa meelo badan oo dhibaato ah;
100 mcg/maalintii xaalado badan ayaa keena luminta xajmiga muruqa iyo xoogga.
Sidan oo kale, Liothyronine sodium, ujeedadu waa in la gaaro cirifka joogtada ah ee luminta baruurta ama in la caawiyo
joogtayso isku-dhaf-shaqsiyeed ku habboonHabkan , qaadashada T3 aad ayuu u hooseeyaa ,
Waxaa la doorbidayaa 12.5 mcg/maalintii laakiin xaaladaha qaarkood ilaa 25 mcg/maalintii.Dhamaadka hoose ee kala duwanaanshahan , sida caadiga ah baaritaanka tayroodhku ma muujin doono cadaadis la ogaan karo xitaa haddii la isticmaalo waqti dheer .Dhamaadka sare , cadaadiska dhexdhexaadka ah ayaa mararka qaarkood la arkaa , laakiin natiijadu way ka sarreeyaan marka T3 aan la qaadin , iyo xakamaynta si degdeg ah ayay dib ugu noqotaa marka la joojiyo isticmaalka T3 .
Si kale haddii loo dhigo , Liothyronine sodium , hadafku waa in la gaaro koror la taaban karo oo ah heerka luminta baruurta , iyadoo qiimaha la og yahay ee kicinta xakamaynta tayroodh.Inta badan la door bidaayo qiyaasta qiyaasta waa qiyaastii 50 mcg / maalin , laakiin xaaladaha qaarkood waxay noqon kartaa ilaa 75 mcg maalintii .Isticmaalka noocan oo kale ah ayaa la doorbidayaa inuusan socon, laakiin kaliya waqti xaddidan sida 8-12 toddobaad, in kasta oo aysan jirin wax shuruud ah oo sax ah oo waqti go'an ah.
T3 VS T4
T4 waxaa deiodinated by saddex deiodinase enzymes si ay u soo saaraan triiodothyronine ka firfircoon.T3 waa hormoonka firfircoon ee firfircoon ee laga soo saaro T4.
Deiodinase enzyme mid ayaa xisaabiya 80% deiodination ee T4, oo ku jira beerka, kelyaha, tayroodh, iyo (ilaa xad ka yar) pituitary.
Deiodinase enzyme laba soo bandhigay CNS, pituitary, dhexdhexaadin jawaab celin taban on thyroid-stimulating hormone, sidoo kale soo bandhigay in nudaha adipose brown brown, iyo xidid wadnaha, kaas oo inta badan waa intracellular.
Deiodinase enzyme saddex, waxay u beddeshaa T4 T3, taas oo ka duwan T3, aan firfircoonayn, waxay ku jirtaa mandheerta, CNS, iyo hemangioma.
T3 COA
| Muuqashada | Budo midab leh oo aan ur lahayn, ku dhawaad cad ama buff | dhaaf |
| Solubility | 1,Aad u yara milmi biyaha | dhaaf |
| 2,wax yar oo khamriga ku milma | dhaaf | |
| 3,dhab ahaan aan milmi karin inta badan dareerayaasha kale ee organic | dhaaf | |
| 4, waxay ku milmaysaa xalalka sodium hydroxide aqueous aqueous | Gudub | |
| Aqoonsiga | a) Kuleyl ku saabsan 50 mg oo leh dhowr dhibcood oo sulfuric acid ah oo ku jira kareemka dhoobada ah: uumiga violet ee iodine ayaa la sameeyay. | dhaaf |
| b) Wakhtiga haynta ee ugu sarraysa waxa loo xaqiijiyaa RS | dhaaf | |
| Khasaare xagga qalajinta | In aan ka badnayn 4.0% | 0.46% |
| [a]20/DC=1 gudaha 1M HCl/EtOH 1:4 | +18 ~ +22o | +20.9o |
| Assay (HPLC) | Aan ka yarayn 95.0% | 99.18% |
| Levothyroxine sodium | In aan ka badnayn 5.0% | 0.68% |
| Gabagabo: | Ilaa heerka Dhoofinta | |
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