Daaweynta Kansarka Exemestane / Aromasin Steroids-ka-hortagga Isteeroodhka ee Goynta / Wareegga Bulking
Faahfaahin Degdeg ah
Exemestane
Magac: Aromasin;Exemestan
Muuqashada: Caddaan ama Ku dhawaad White Budada Crystalline
Waxyaabaha ku jira badeecada: ≥ 99% CAS: 107868-30-4
Qaaciddada molecular: C20H24O2
Miisaanka Molecular:296.40
Isticmaal: loo isticmaalo daawaynta kansarka naasaha ee metastatic .oo loo isticmaalo gargaar ahaan daawaynta kansarka naasaha ee hore.
Waxa kale oo aad maqli kartaa iyada oo loo yaqaan Aromasin, oo ah magaca caanka ah ee ugu caansan.Waxaa jira tiro ka mid ah noocyada kale ee exemestane, kuwaas oo dhamaantood ka kooban isla qiyaasta daawada.
Talooyin qiyaasta
Qiyaasta Caadiga ah ee Qaangaarka ee Kansarka Naasaha:
25 mg afka hal mar maalintii
Faallo:
- Dawadan waa in la qaataa cuntada ka dib.
Adeegsada:
- Daaweynta adjuvant ee dumarka postmenopausal leh estrogen-receptor togan kansarka naasaha hore kuwaas oo helay laba ilaa saddex sano ee tamoxifen oo loo beddelay exemestane si loo dhamaystiro wadarta shan sano oo isku xigta ee daaweynta hoormoonka adjuvant.
- Daawaynta kansarka naasaha ee horumaray ee dumarka menopause ee ka dambeeya kuwaas oo cudurkoodu sii kordhay ka dib daawaynta tamoxifen.
Sharaxaada
Aromasin (Exemestane acetate) waa mid ka mid ah xeryahooda yaabka leh ee aan cidina garanayn waxa lagu sameeyo.Waa jiilka saddexaad ee Aromatase Inhibitor (AI) sida Arimidex (Anastrozole) iyo Femera (Letrozole).
jiilka saddexaad ee aromatase inhibitors, oo loo isticmaalo daawaynta kansarka naasaha ee metastatic oo loo isticmaalo gargaarka daaweynta kansarka naasaha hore.
● Aromasin waa mid ka mid ah iskudhisyada xakameynaya estrogen ee ugu awoodda badan.
Aromasin waa mid ka mid ah xeryahooda ugu fiican si loo yareeyo saameynta udugga ee steroids.
● Aromasin ayaa diyaar u ah dhisayaasha jirka ee qaata steroids anabolic.
Aromasin waxa kale oo loo yaqaan Exemestane.
● Waxay u shaqeysaa iyadoo xannibaysa aromatase enzyme, ka dibna xannibaysa soo saarista estrogen.
Aromasin sidoo kale waa nooc ka mid ah .antineoplastic (hormoonka) alaabta ceeriin.
Aromasin waxaa loo isticmaalaa in lagula dagaallamo kansarka naasaha iyo kor u qaadista testosterone ee jirka.
Exemestane wuxuu xannibaa habka udugga.Markaa waxay hoos u dhigtaa qiyaasta estrogen ee jirka.Marka hore ee kansarka naasaha, qaadashada exemestane waxay kaa caawin kartaa joojinta soo noqoshada kansarka naasaha.Kansarka naasaha ee horumarsan waxaa laga yaabaa in unugyada kansarku si tartiib tartiib ah u koraan ama ay joojiyaan koritaanka gebi ahaanba.
Exemestane waa inhibitor aromatase.Tani waxay ka dhigan tahay in ay xannibayso aromatase enzyme (laga helo muruqa jidhka, maqaarka, naaska iyo baruurta), kaas oo loo isticmaalo in lagu beddelo androgens (hormoonnada ay soo saaraan qanjidhada adrenal) ee estrogen.Maqnaanshaha estrogen-ka, burooyinka ku tiirsan hormoonkan koritaanka ayaa yaraan doona
Faa'iidooyinka Exemestane
>>.Dhismaha jidhka
Steroidal Exemestane inhibitor oo u dhaqma iyadoo hoos u dhigaysa qadarka estrogen ee uu soo saaro jirku.Waxay u shaqeysaa iyada oo xaddidaysa beddelka Testosterone ee estrogen iyo celceliska heerka xakamaynta estrogen waa 85%.Daroogadu waxay sidoo kale hoos u dhigtaa heerarka estradiol ee ku saabsan 50%, iyo sidoo kale si weyn u kordhiya heerarka testosterone.
Exemestane inhibitor oo ka shaqeeya xakameynaya isku dhafka estrogen.Waa wax ku ool ah kordhinta testosterone iyo heerarka IGF ee jirka.Daroogadu sidoo kale aad bay faa'iido u leedahay inta lagu jiro nidaamka daaweynta wareegga dambe marka qofku isku dayayo inuu soo celiyo heerarka dabiiciga ah ee Testosterone si looga fogaado shilalka wareegga dambe.
>>.Dawada ka hortagta estrogen
Iyadoo loo aqoonsan yahay mid ka mid ah dawooyinka ugu qaalisan, Exemestane waa mid ka mid ah dawooyinka anti-estrogen-ka ee ugu ammaansan oo ay inta badan isticmaalaan ciyaartoyda iyo kuwa jir-dhisayaasha.Caafimaad ahaan dawada waxaa inta badan loo qoraa daawaynta kansarka naasaha.Caadi ahaan loo yaqaan 'Selective Estrogen Rector Modulator' (SERM) , waxa hore loogu isticmaalay ka-hortagga gynocomastia.
Tusmada ugu hooseysa ee Exemestane
A)Exemestane ee ka hortagga kansarka naasaha:
Chemoprevention ee kansarka naasaha waa istaraatijiyad wax ku ool ah si loo yareeyo dhacdooyinka cudurkaan ee haweenka halista ugu jira.Wakiilada ugu horreeya ee muujiya saameyn muhiim ah oo ka hortag ah waxay ahaayeen SERMs tamoxifen iyo raloxifen.
Falanqaynta dhammaystiran ee la cusboonaysiiyay ee dhammaan tijaabooyinka ka hortagga SERM waxay muujisay inay awoodaan inay yareeyaan dhacdooyinka kansarka naasaha ee haweenka khatarta sare leh iyo kuwa dhexdhexaadka ah, saamaynta ay ku sii socoto hoos u dhigista kansarka naasaha ee ER-positive.
B)Exemestane waa jiil saddexaad oo aan la beddeli karin steroidal inactivator ee aromatase enzyme waxayna wax ku ool u tahay dhammaan goobaha daaweynta kansarka naasaha, oo ay ku jiraan kiimiko ka hortagga.
Goobta metastatic, exemestane ayaa si weyn loo baaray sida line-ka koowaad, line-labaad, iyo daawaynta dheeraadka ah oo hadda loo diiwaan geliyey daawaynta dumarka postmenopausal oo leh hormone-receptor-hormoon kansarka naasaha togan kaas oo cudurku sii kordhay ka dib antiestrogen daawaynta
Xusuusnow, la'aanta suurtagalka ah ee iska caabbinta isdhaafsiga ee NSAI waxay soo saartaa fursado dheeraad ah oo ku saabsan habka daaweynta ee wakiilada endocrine.Intaa waxaa dheer, oo ku saleysan natiijooyinka kiliinikada ee macnaha leh, exemestane with everolimus waxay u taagan tahay doorasho daaweyneed oo wax ku ool ah oo loogu talagalay cudur ka soo baxay ka dib soo-gaadhista NSAI.
Exemestane guud ahaan si fiican ayaa loo dulqaatay, iyada oo leh muuqaal saameyneed oo la mid ah kuwa AIs kale oo ay ku jiraan calaamadaha menopausal, arthralgia, luminta lafaha, iyo dheef-shiid kiimikaad oo isbeddelay.
